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Centrophenoxine

Centrophenoxine is to DMAE like Alpha-GPC is to Choline, an option that is better absorbed since the active molecule is bound to an absorption enhancer. Centrophenoxine carries the benefits of DMAE, and may boost cognition in the elderly.

Our evidence-based analysis on centrophenoxine features 4 unique references to scientific papers.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 2, 2013
Last Updated:

Summary of Centrophenoxine

Primary Information, Benefits, Effects, and Important Facts

Centrophenoxine is a cholinergic compound with a DMAE (Dimethylaminoethanol) component, and acts as a better absorbed transporter of DMAE into the brain. It is sold under the brand name Lucidril but can easily be bought over the counter or online.

It is effective in reversing some of the signs of aging (particularly waste product buildup in the brain) when taken for an acute period (high doses for a month) and can act as a general neural enhancer and protector when taken continuously at a lower dose.

Things To Know & Note

Is a Form Of

Also Known As

Centro, Lucidril (Brand Name)

Goes Well With

Racetams

Centrophenoxine, via increasing acetylcholine levels, is stimulatory.

How to Take Centrophenoxine

Recommended dosage, active amounts, other details

For therapeutic usage in reducing lipofuscin (for the aged) 3-6 doses of 250mg centrophenoxine is generally touted.

For younger individuals seeking neurological enhancement and neuronal protection, 1-3 doses of 250mg suffices.

Scientific Research on Centrophenoxine

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Centrophenoxine is able to reverse lipofuscin/beta-amyloid pigmentation build-up as well as act as an anti-oxidant against lipid peroxidation.[1] Centrophenoxine can also increase RNA synthesis, protein synthesis, and glucose uptake in neurons and glial (support) cells. These latter effects are, however, dependent on the reductions of lipofuscin build-up[2] and don't appear to affect youth with no lipofuscin build-up.[3]

Centrophenoxine has been shown to be efficacious in treating dementia by increasing intracellular water content (of which dehydration is consistent with aging) and by increasing skills on cognition testing after 8 weeks of a 2g dose.[4]

Centrophenoxine, via its DMAE moiety, may act as a teratogen in the same manner as DMAE which can be reviewed under DMAE's Teratogenic Summary

References

  1. ^ Sharma D, Maurya AK, Singh R. Age-related decline in multiple unit action potentials of CA3 region of rat hippocampus: correlation with lipid peroxidation and lipofuscin concentration and the effect of centrophenoxine. Neurobiol Aging. (1993)
  2. ^ Ludwig-Festl M, Gräter B, Bayreuther K. Increase in cell metabolism in normal, diploid human glial cells in stationary cell cultures induced by meclofenoxate. Arzneimittelforschung. (1983)
  3. ^ Watanabe S, et al. Effects of various cerebral metabolic activators on glucose metabolism of brain. Folia Psychiatr Neurol Jpn. (1975)
  4. ^ Fülöp T Jr, et al. Effects of centrophenoxine on body composition and some biochemical parameters of demented elderly people as revealed in a double-blind clinical trial. Arch Gerontol Geriatr. (1990)