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Adiponectin

Adiponectin is an adipokine (signalling molecule secreted from fat cells, like leptin) which positively influences glucose metabolism and fat loss. Increasing adiponectin levels are thought to result in fat loss and improved health.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect adiponectin
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b - High See all 3 studies
No alterations in adiponectin has been noted with CLA supplementation
grade-c Notable Very High See 2 studies
An increase in circulating adiponectin has been noted in subjects with health ailments (NAFLD or metabolic syndrome) to a moderate degree
grade-c Minor - See study
At least in persons with impaired glucose tolerance, an increase in adiponectin (and the adiponectin:leptin ratio) has been noted with supplemental L-arginine
grade-c Minor Very High See all 3 studies
Curcumin has been implicated in increasing adiponectin concentrations.
grade-c Minor - See study
There appears to be an increase in adiponectin associated with 1,200mg of aged garlic supplementation despite no other influence on the body of persons with metabolic syndrome.
grade-c Minor - See study
Possible increase in adiponectin associated with green tea ingestion
grade-c Minor - See study
An increase in adiponectin has been noted in women with PCOS
grade-c Minor - See study
An increase in adiponectin is noted with irvingia gabonensis, but this result is somewhat unreliable due to being confounded with both weight loss and industry influence
grade-c Minor - See study
An increase in adiponectin has been noted
grade-c Minor - See study
An increase in adiponectin has been noted following acute ingestion of melatonin
grade-c - - See study
grade-c - Very High See 2 studies
No significant influences on adiponectin concentrations in the blood relative to placebo.
grade-c - - See study
No significant influence on circulating adiponectin concentrations when compared to control.
grade-c - - See study
No detectable interaction of CoQ10 and adiponectin
grade-c - Moderate See 2 studies
No significant influence on Adiponectin concentrations
grade-c - - See study
No significant interaction between adiponectin and licorice
grade-c - - See study
No significant influence on adiponectin concentrations
grade-c - - See study
No significant modifications in adiponectin concentrations when rose hip supplementation is given to humans.
grade-c - - See study
No significant influence on adiponectin concentrations in persons with fatty liver seen with betaine supplementation.
grade-c - - See study
No significant alterations seen in adiponectin concentrations in serum with 4 weeks supplementation of 30mg MK-4
grade-d Minor - See study
An increase in adiponectin has been associated with coffee consumption
grade-d - - See study
No significant influence on adiponectin concentrations in obese individuals
grade-d - - See study
No statistically significant effect of 200, 500 and 1000 mg/d for 14 days on postprandial levels.