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Apolipoprotein A

Apolipoprotein A is the apolipoprotein for HDL cholesterol, and increasing its concentrations promotes flux of fatty acids and molecules that are carried on lipoproteins away from peripheral tissue and towards the liver.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect apolipoprotein a
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b - High See all 4 studies
A large decrease has been noted in one study in overweight postmenopausal women, although three other studies failed to replicate this decrease.
grade-c Minor - See study
In high risk individuals, the reduction has been noted to be 23.4+/-7.9%
grade-c Minor - See study
An increase in Apolipoprotein A1 has been noted with supplementation of betaine relative to placebo in otherwise healthy persons.
- See all 4 studies
Mixed evidence, including null evidence, in different populations as to whether apolipoprotein AI is increased or decreased; one study in subjects with low HDL-C noted an increased (which would be cardioprotective).
grade-c Minor - See study
A slight increase in apolipoprotein A has been reported in obese persons who may have been zinc deficient, but then supplemented to alleviate said deficiency.
grade-c - - See study
grade-c - - See study
No known interactions with Apolipoprotein A.
grade-c - Very High See 2 studies
No significant influence on Apolipoprotein A concentrations
grade-c - - See study
No significant influence on Apolipoprotein A seen with supplementation of hesperidin.
grade-c - - See study
grade-d Minor - See study
A decrease in Apolipoprotein A has been noted with krill oil supplementation
grade-d - Very High See 2 studies
No apparent effect in studies.
grade-d - - See study
No significant influence on apolipoprotein A levels in serum
grade-d - - See study