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Arterial Stiffness

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Arterial Stiffness

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Arterial Stiffness

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect arterial stiffness
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor Very High See 2 studies
Mixed evidence as to whether cocoa flavanols can decrease arterial stiffness in otherwise healthy adults, with the one study coming back positive being conducted in overweight adults
grade-c Minor Very High See 2 studies
There appears to be a reduction in arterial stiffness seen with daily supplementation of garlic when measured over the course of a few years, relative to no garlic ingestion.
grade-c Minor Very High See 2 studies
Short term supplementation of red clover isoflavones appears to reduce arterial stiffness in a manner independent of changes in blood pressure or flow.
grade-c Minor - See study
Mixed evidence, but vitamin E has been implicated in improving arterial stiffness (thought to underlie decreased cardiovascular mortality)
grade-d Minor - See study
May affect brachial-ankle measures of stiffness, but does not affect carotid-femoral stiffness.
grade-d - Moderate See 2 studies
No apparent effect in one study.