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Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Bilirubin

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Bilirubin

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect bilirubin
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b - - See all 3 studies
grade-c Minor - See study
The increase in bilirubin seen with hoodia is thought to be a biomarker of possible hepatotoxicity, although it was not met with hemolysis (usually accompanies)
grade-c Minor - See study
Supplemental picrorhiza kurroa can reduce bilirubin in a model of acute viral hepatitis, although no comparisons to reference drugs have yet been made.
grade-c - - See 2 studies
grade-c - - See study
No significant interactions with bilirubin concentrations in serum.
grade-c - - See study
grade-c - - See all 3 studies
grade-c - Very High See 2 studies
Despite treating the viral load of hepatitis C, no significant changes in serum bilirubin exist.
grade-c - - See study
No significant alterations in serum bilirubin seen with supplementation
grade-c - Very High See 2 studies
Serum bilirubin does not appear to be influenced with supplementation of vitamin E relative to placebo.
grade-d Minor - See study
One study in dyslipidemics found an increase in bilirubin associated with niacin supplementation.
grade-d - Low See all 3 studies
It's unclear if it has much of an effect from the limited research.
grade-d - - See study
The reduction in bilirubin seen with this herb failed to reach statistical significance when used in a clinical setting.