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Endothelial Function

Endothelial function (vasoreactivity) tends to refer to the reactivity of blood vessels to dilate or contract upon demand, and is associated with blood flow and arterial calcification. Improved vasoreactivity is associated with reduced risk for cardiovascular incidents.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect endothelial function
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor Very High See all 5 studies
The effective size does not appear to be overly large, but CoQ10 is associated with a protective effect on blood flow and endothelial function in persons with otherwise impaired function.
grade-b Minor Very High See all 4 studies
There appears to be a slight increase in vascular reactivity and blood vessel responsiveness that may be independent of both blood flow alterations and blood pressure
grade-c Minor Moderate See 2 studies
Unreliable improvements in endothelial function, notably in persons with impaired glucose tolerance/type II diabetes, associated with the supposed increase in nitric oxide
grade-c Minor Moderate See 2 studies
A possible increase in endothelial reactivity is noted with panax ginseng supplementation
grade-c - - See study
No significant influence on endothelial function
grade-d Minor High See all 3 studies
Attenuation of impairment due to either acute hyperglycemia or elevated free fatty acid levels
grade-d - - See study
No apparent effect in one study.