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Exercise Capacity (with Heart Conditions)

Cardiovascular exercise is known to be impaired in persons with heart disorders and supplements are being investigated to see whether the performance enhancing effects in healthy subjects can be extended to these persons.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect exercise capacity (with heart conditions)
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Minor Very High See all 4 studies
Appears to aid exercise capacity in persons after myocardial infarction
grade-b - Very High See all 3 studies
Although there may be a small reduction of power output (typical of creatine), the main parameter of interest (cardiorespiratory output) is mostly unaffected by creatine supplementation.
grade-c Minor - See study
A positive effect, but the potency thereof was not overly remarkable
grade-c Minor Moderate See 2 studies
Although a failure has been noted in persons with COPD, one study has noted acute benefits in chronic stable angina with 80mg/kg oral glutamine supplementation.
grade-d Minor - See study
Citrulline has been noted to increase physical exercise capacity in persons with heart failure.
grade-d Minor - See study
In persons with coronary heart disease, supplementation of garlic appears to increase physical performance when ingested at a food dose (1g) daily over six weeks; the increase in performance is moderate.
grade-d Minor - See study
An improvement in walking distance has been noted