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Growth Hormone

Growth hormone (GH) is a peptide hormone that regulates growth in youth, and in adults is thought to promote fat loss and longevity. Increasing growth hormone should improve these goals, but supplements are currently lacklustre.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Things To Know & Note

Also Known As


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect growth hormone
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
- See all 5 studies
Arginine has been implicated in increasing growth hormone (at rest) and suppressing an exercise-induced increase in growth hormone; both of these are short in duration, and it is unsure if there are any long lasting effects of such short a spike.
- See all 4 studies
During exercise, creatine supplementation can suppress growth hormone secretion: up to 35% during loading; up to 5% during maintenance. At rest, creatine supplementation can spike growth hormone by up to 83±45%. This bidirectional effect is similar to that of arginine supplementation.
grade-c Minor Very High See 2 studies
Has noted an increase in circulating growth hormone, but measurements were acute (whole-day measurements of growth hormone are more reliable due to hourly fluctuations)
grade-c Minor Very High See 2 studies
An increase in growth hormone has been noted with exercise, but not at rest. Practical significance of this information is unknown, since Arginine supplementation has unreliable effects itself
grade-c Minor Moderate See 2 studies
Appears to increase circulating levels of growth hormone
grade-c Minor - See study
An acute suppression of growth hormone has been noted with nicotine to a small degree
grade-c - - See study
The kinetics of growth hormone release from exercise are not influenced by alanylglutamine relative to water.
grade-c - - See study
grade-c - - See study
No significant alterations in growth hormone following ingestion of gamma-oryzanol
grade-c - - See study
Serum growth hormone is not significantly altered with HMB supplementation in athletes
grade-c - - See study
The minor increase in growth hormone seen with betaine (6.1%), relative to placebo, failed to reach statistical significance and is too low of magnitude to consider it practically appreciable.
grade-c - - See study
No significant influence on growth hormone levels
grade-d Minor - See study
An acute suppression of growth hormone is noted with alcohol ingestion
grade-d Minor Moderate See 2 studies
May increase growth hormone concentrations, but this appears to be unreliable
grade-d - - See study
There does not appear to be a significant influence of colostrum supplementation on circulating GH following oral supplementation relative to other protein sources.
grade-d - - See study
No significant influence on exercise-induced growth hormone
grade-d - - See 2 studies