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Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Hemoglobin

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Hemoglobin

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect hemoglobin
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b - - See study
grade-c Minor - See study
Hemoglobin has been noted to be decreased in one study and thought to be related to possible toxic effects of moderately high dose saffron (60mg for more than 8 weeks).
grade-c - Very High See 2 studies
There does not appear to be an inherent increase in hemoglobin with colostrum, although when it successfully treated HIV-associated diarrhea an increase in hemoglobin was noted once (thought to partially underlie the reduction in fatigue).
grade-c - - See study
grade-c - - See study
No significant influence of vitamin E supplementation on hemoglobin.
grade-d Minor - See study
Small drops in hemoglobin were noted in vitamin D-insufficient healthy people supplemented with 800 IU over 12 weeks.
grade-d Moderate See 2 studies
A slight but significant 6.3% increase in hemoglobin has been detected in otherwise healthy persons given ashwagandha daily for a period of 60 days. However, another study found a slight decrease in healthy subjects after 12 weeks.
grade-d - High See all 3 studies
Inconsistent evidence from 3 studies. Much more research is needed.