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Immunoglobulin A

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Immunoglobulin A

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Immunoglobulin A

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect immunoglobulin a
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b - Moderate See all 8 studies
IgA concentrations in saliva and serum do not appear to be reliably increased although a few studies have noted spikes, which do not appear to be consistent in their magnitude nor incidence. The only incidence where IgA appears to be reliably increased is when it is taken as a vaccine adjuvant.
grade-c Notable - See study
The decrease in Immunoglobulin A noted with exercise in one study in marathon runners (60% relative to baseline) was reversed to a large increase (194% relative to baseline) when measured after exercise.
grade-c - - See study
grade-c - - See study
No significant influence on circulating IgA concentrations following saffron ingestion.
grade-c - - See study
grade-c - - See study
Supplementation of vitamin E does not appear to significantly influence circulating concentrations of IgA relative to placebo in otherwise healthy elderly adults.
grade-d Minor Moderate See 2 studies
Raised salivary IgA but not serum IgA in one study.