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Interleukin 6

Interleukin 6 (IL-6) is a proinflammatory cytokine that is thought to reflect a more inflammatory state in the body.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Things To Know & Note

Also Known As


Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect interleukin 6
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor Very High See all 4 studies
A slight decrease in IL-6 concentrations has been noted, practical relevance unknown.
grade-c Minor - See study
A decrease in circulating IL-6 has been noted with fish oil supplementation
grade-c Minor - See study
A slight reduction in IL-6 has been reported in persons who are diagnosed with metabolic syndrome
grade-c Minor Moderate See 2 studies
Alongside other proinflammatory cytokines, IL-6 appears to be reduced following supplementation of zinc.
grade-c - - See study
Interleukin-6 does not appear to be influenced during exercise when alanylglutamine is increased prior as rehydration (relative to water)
grade-c - Very High See 2 studies
No significant influence on IL-6 concentrations in serum
grade-c - Very High See all 4 studies
Serum interleukin six (IL-6), a biomarker of inflammation, does not appear to be altered in response to supplementation of cocoa.
grade-c - Very High See 2 studies
IL-6 does not appear to be influenced with supplementation of colostrum.
grade-c - Very High See 2 studies
Supplementation of garlic to persons in chronic pro-inflammatory states does not seem to significantly influence circulating IL-6 concentrations
grade-c - - See study
No significant alterations in circulating IL-6 concentrations
grade-c - - See study
No significant influence on interleukin 6 (IL-6) is seen with oral supplementation of hesperidin.
grade-c - - See study
grade-c - - See study
The alterations in IL-6 concentrations seen with exercise are unchanged with quercetin supplementation.
grade-c - - See study
The inflammatory cytokine IL-6 does not appear to be influenced by supplementation of niacin.
grade-c - Low See all 4 studies
Mixed evidence. One study found a significant reduction compared with placebo after 8 weeks supplementation, one study found a non-significant increase in response to ultramarathon running, and one study found no change.
grade-c - - See study
IL-6 concentrations do not appear to be influenced relative to placebo.
grade-c - Very High See 2 studies
No significant effect of vitamin K on circulating levels of IL-6, an inflammatory marker
grade-d Minor - See study
There is a minor decrease in circulating IL-6 associated with iodine supplementation, thought to be indicative of a minor antiinflammatory effect.
grade-d Minor - See study
IL-6 appeared to be significantly reduced in the serum of adults given PQQ supplementation relative to baseline.
grade-d - - See study
No apparent effect in schizophrenia patients in one study.
grade-d - - See study