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Intestinal Permeability

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Intestinal Permeability

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Intestinal Permeability

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect intestinal permeability
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b
Minor
- See all 3 studies
Evidence is preliminary, and there are studies suggesting both an increase in permeability and a decrease seen with endurance exercise (increase) or with high heat stress exercise or NSAID coingestion (decrease).
grade-c Minor - See study
In subjects with HIV who reported diarrhea in the last two weeks, supplementation of alanylglutamine was more effective than placebo (glycine) in reducing intestinal permeability
grade-c Minor - See study
An increase in the amount of intestinal permeability induced by training in the heat has been noted with quercetin supplementation, which is an adverse event; the influence of quercetin at rest is uncertain
grade-c - - See study
grade-d Minor - See study
Appears to decrease intestinal permeability, which is due to the glutamine content of whey protein.