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Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Irritability

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Irritability

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect irritability
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor - See study
Irritability as a side-effect of PMS has been reduced with supplemental krill oil
grade-c Minor - See study
Irritability as a side-effect of tension headaches is reduced secondary to the treatment of tension headaches
grade-c Minor Very High See 2 studies
Can reduce irritability as a side effect of PMS, no evidence as to whether this reduction in irritability applies to other persons (males) or periods that are not PMS.
grade-c - Very High See 2 studies
Irritability as a side effect of multiple sclerosis does not appear to be significantly affected by marijuana therapy.
grade-c - - See 2 studies
grade-d Notable - See study
Reduction in one industry-funded study of chronically stressed people. Needs to be replicated.
grade-d Minor - See study
Decrease in irritability seen with Royal Jelly may be secondary to reducing the symptoms of menopause