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Ketone Bodies

Ketone bodies are small molecules that are produced in higher amounts during states of carbohydrate depletion, and are known to contribute to energy metabolism and may influence other aspects of the body.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect ketone bodies
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor - See study
An increase in ketone bodies has been noted when fish oil is paired with a weight loss diet (relative to placebo)
grade-c - - See study
No significant alterations in formation of ketone bodies, which may be due to the ketogenic BCAA (leucine) being offset by the other two glucogenic ones
grade-d Minor - See study
A decrease in ketone bodies in type II diabetics was noted with supplementation of colostrum daily for four weeks; the decrease was mild, and there was no protein containing placebo for comparison.
grade-d Minor - See study
Has been implicated in increasing serum ketones more than other fatty acids.
grade-d Minor Very High See 2 studies
During fasting or ketogenic diets, sodium bicarbonate supplementation may be able to increase ketone body production. This appears to be of somewhat small magnitude and was not associated with additional fat loss
grade-d Minor - See study
Supplementation of low dose niacin (100mg) repeatedly while in the fasted state appears to be associated with an increase in blood ketone levels.