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Lactate Production

Lactate can be produced during prolonged exercise, and while it is not thought to contribute to muscular failure it seems to be a good biomarker of it. Reductions in lactate production tend to be associated with prolonged physical endurance.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect lactate production
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
- See all 37 studies
Increases of lactate production are noted in short intense exercises (due to allowing more work to be conducted, and the work produces more lactate) while prolonged exercise is associated with a decrease in lactate concentrations relative to placebo
grade-b Minor Very High See all 6 studies
Seems to increase lactate production during exercise when caffeine is acutely preloaded
grade-b Minor Moderate See all 5 studies
Lactate production appears to be decreased in studies that note an increase in muscular carnitine stores, although the decrease is not overly notable
grade-b - High See all 3 studies
There does not appear to be any reliable or significant changes in blood lactate concentrations following exercise with BCAA supplementation
grade-b - Very High See all 4 studies
Lactate production during physical exercise does not appear to be any different with dietary colostrum when compared to whey protein.
grade-b - Moderate See all 6 studies
No apparent reduction or increase in lactate in swimmers after sprinting exercises.
grade-b - High See all 3 studies
An attenuation in the rise of lactate seen in more endurance based exercise may need to be replicated, since two other studies (majority of evidence) have failed to find an interaction with betaine ingestion and lactate.
grade-c Minor Moderate See 2 studies
Mixed evidence, but at least one study has noted that lactate production during exercise was greater with 600mcg chromium than it was with placebo; no known mechanism for this observation.
grade-c Minor - See study
A decrease in lactate has been noted one hour into training in heat, with no significant influence prior to one hour
grade-c Minor - See study
A decrease in lactate production has been noted with rhodiola supplementation; practical significance unknown
grade-c - - See study
Lactate production and serum levels during a cycle to fatigue do not appear to differ between alanylglutamine and water
grade-c - - See study
No significant influence on lactate production associated with L-arginine supplementation
grade-c - - See study
grade-c - - See study
No significant influence on lactate production seen with citrulline supplementation before exercise
grade-c - - See study
Lactate production during exercise does not appear to be influenced with supplementation of vitamin E.
grade-c - - See study
At rest and during exercise there does not seem to be any major modification of lactate levels in serum.
grade-d - - See study
The rate of lactate accumulation and production during exercise does not appear to be significantly influenced by pre-exercise supplementation of cocoa flavanols
grade-d - - See study
No significant influence on exercise-induced lactate production