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Lipid Peroxidation

A form of oxidation that influences lipids. In the body, it tends to reflect damage to cell membranes and is assessed by biomarkers thought to represent lipid peroxidation (MDA and TBARS).

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Apr 20, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect lipid peroxidation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 4 studies
Appears to reduce biomarkers of lipid peroxidation. CoQ10 tends to be a reference drug for lipid peroxidation, and although it is more potent than other nutraceuticals it is not astounding.
grade-b Notable Very High See all 3 studies
Although there is no reference drug to compare the effects of Spirulina against, the decrease in lipid peroxidation as assessed by serum MDA is quite notable and is likely stronger than other supplements. A comparative study would be needed
grade-b
Minor
- See all 5 studies
While minor, increases in lipid peroxidation have been noted in nondiabetic controls while decreases have occurred in those with a high baseline HbA1c. A possible modulatory effect exists.
grade-b Minor Low See all 3 studies
A minor reduction has been observed.
grade-b Minor Very High See all 6 studies
A decrease in lipid peroxidation results following curcumin ingestion chronically
grade-b
Minor
- See all 5 studies
Both increases and decreases in lipid peroxidation have been noted with fish oil supplementation, with the increases in peroxidation usually seen with high doses of fish oil paired with other oxidative stressors (such as marathon running)
grade-b Minor Very High See all 3 studies
The reduction in MDA that occurs during exercise may also occur at rest, suggesting a per se effect
grade-b Minor Low See all 8 studies
Mixed and weak influences on lipid peroxidation, but a possible reduction exists
grade-b
Minor
- See all 7 studies
Vitamin E tends to reduce lipid peroxidation in instances where there is elevated oxidation, and tends to have no effect in otherwise healthy persons. In instances where vitamin E is thought to greatly exceed the activity of co-antioxidants (vitamin C or ALA) it can exert a prooxidant effect.
grade-b Minor Very High See all 3 studies
A slight decrease in lipid peroxidation has been noted with supplementation of zinc in persons who may be deficient.
grade-b - - See all 4 studies
grade-c Minor Very High See 2 studies
Appears to reduce biomarkers of lipid peroxidation (MDA mostly)
grade-c Minor - See study
A minor reduction in lipid peroxidation has been seen in serum associated with weight loss; uncertain significance.
grade-c Minor Moderate See all 4 studies
Decreases in lipid peroxidation (assessed by serum MDA) have been noted in oxidative states such as exercise, but have not been noted in resting states after cocoa flavanol ingestion.
grade-c Minor - See all 3 studies
A reduction in lipid peroxidation in the blood and in red blood cells has been noted in some states of metabolic ailment (aging and hypertension). Not 100% reliable as it wasn't seen in one study on hypercholesterolemia, and no studies in healthy controls.
grade-c Minor - See study
A minor decrease in lipid peroxidation has been noted with supplementation of low doses
grade-c Minor Very High See 2 studies
A decrease in lipid peroxidation is noted with licorice consumption, not to a remarkable degree
grade-c Minor - See study
A reduction in lipid peroxidation has been noted with melatonin
grade-c Minor - See study
A decrease in exercise-induced lipid peroxidation is noted as assessed by serum MDA
grade-c Minor Very High See 2 studies
Appears to reduce biomarkers of lipid peroxidation.
grade-c Minor - See study
A decrease in lipid peroxidation has been noted following oral ingestion of Rooibos tea
grade-c Minor - See study
A decrease in lipid peroxidation (assessed by MDA) has been noted in serum and semen following oral ingestion of shilajit
grade-c - - See study
Alanylglutamine does not appear to have any influence on lipid peroxidation (MDA) concentrations during exercise relative to glutamine or water control.
grade-c - - See study
No significant influence of citrulline on lipid peroxidation has been noted
grade-c - - See study
Insufficient evidence to evaluate lipid peroxidation reducing effects
grade-c - Very High See 2 studies
No significant changes in lipid peroxidation biomarkers (such as MDA) are present following ingestion of Reishi
grade-c - - See study
grade-c - - See study
No known interactions with serum MDA concentrations, a biomarker of lipid peroxidation.
grade-c - Very High See 2 studies
No significant influences on lipid peroxidation biomarkers in serum
grade-c - - See study
No significant effect on lipid peroxidation has been noted.
grade-c - - See study
No significant alterations have been noted in circulating biomarkers of lipid peroxidation.
grade-d Notable - See study
Definitely requires more evidence, but appears to be fairly effective at reducing lipid peroxidation and other oxidative parameters (lone study noting a 40% reduction with aronia)
grade-d Notable - See study
In the semen of infertile men, the reduction in lipid peroxidation has reached 53.7% with supplementation of ginger over three months.
grade-d Minor - See study
One study noted a modest reduction in malondialdehyde levels in healthy people. More research is needed.
grade-d Minor - See study
Alongside the reduction in serum oxidation comes a reduction in lipid peroxidation biomarkers such as MDA
grade-d Minor - See study
A decrease in biomarkers of lipid peroxidation has been noted, possible related to an increase in serum Vitamin E concentrations
grade-d Minor - See study
Can decrease biomarkers of lipid peroxidation
grade-d Minor - See study
Has been noted to reduce lipid peroxidation
grade-d Minor - See study
A slight decrease in biomarkers of lipid peroxidation occurs following ingestion of lemon balm
grade-d Minor - See study
A decrease in lipid peroxidation has been noted
grade-d Minor - See study
Although a decrease technically exists as assessed by TBARS, the decrease was measured at around 0.2% and is practically irrelevant.
grade-d Minor - See study
In otherwise healthy men with no apparent health problems, there is a mild decrease in lipid peroxidation associated with consumption of the berries (12% reduction in MDA)
grade-d Minor - See study
A minor decrease in levels of lipid peroxidation in serum were noted, to the tune of 17%.
grade-d Minor - See study
A decrease in lipid peroxidation has been noted with Mate consumption over 7 days
grade-d - - See study
Despite containing PUFAs, no significant changes in lipid peroxidation
grade-d - - See study