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Liver Fat

Liver fat refers to the triglycerides that can be stored in the liver, of which their excess accumulations results in fatty liver (alcohol or non-alcoholic) and possibly later cirrhosis. Some supplements may be able to reduce liver fat stores.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect liver fat
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Notable - See study
The decrease in liver fat seen with fucoxanthin tends to be greater than that seen with other supplements, although insufficient evidence exists to suggest reliability of results
grade-c Minor - See study
A possible decreasing effect of liver fat seen in persons with NAFLD
grade-c Minor Very High See all 3 studies
Preliminary evidence showed a major decrease in liver fat (normalization in over half of persons with fatty liver) but currently the best evidence suggests that this does not occur as potently; there may still be a role, but this requires more research.
grade-c Minor Very High See all 3 studies
In persons with steatohepatitis, there may be a reduction in liver fat over time when taking vitamin E supplements; currently there is no evidence assessing otherwise healthy persons on this parameter
grade-d Strong - See study
Although only based on a series of case studies at this moment in time, the reduction of liver fat seen after 3 months was remarkably effective
grade-d Minor Very High See 2 studies
Reductions in liver fat have been noted with whey protein supplementation, which is thought to be more effective than other protein sources due to the high L-cysteine content.
grade-d - High See all 3 studies
Inconsistent evidence from non-alcoholic fatty liver disease.