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Natural Killer Cell Activity

Natural Killer Cell Activity refers to the ability of natural killer cells to do their actions in the body, and this activity can be increased either by increasing cell count of promoting activity in a direct stimulatory manner.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect natural killer cell activity
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 3 studies
Although there do not appear to be changes in the amounts of NK cells in the body following fish oil, their activity appears to be a tad reduced
grade-c Minor Moderate See 2 studies
There is an increase in NK cell activity alongside the increase in NK cell content, although it is not sure if there is an inherent increase in NK cell activity if you control for the increase in cell content.
grade-c - - See study
The phagocytic activity of natural killer cells does not appear to be modified with supplementation of colostrum relative to whey control.
grade-c - - See study
grade-c - - See study
Natural Killer (NK) cell activity does not appear to be influenced with supplementation of hesperidin, with the count also remaining unchanged.
grade-d Notable - See study
Up to a 50% increase in NK cell activity relative to control has been noted with reishi, and this may be independent of a basic stimulatory action (which would lead into possible supplement combinations)
grade-d Notable - See study
NK cell activity against a tumor cell line (K562) increased 40% following a week ingestion of fairly reasonable oral dosing, suggesting that this is a notable increase of possible interest.
grade-d Minor - See study
A slight increase in natural killer cell activity has been noted with ashwagandha supplementation.
grade-d - - See study
No significant alterations in NK cell activity