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Noradrenaline is a catecholamine involved in the flight or fight response, and has a fairly important role as a neurotransmitter in the body. Elevations of serum noradrenline are thought to reflect increases in cerebral noradrenaline.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Things To Know & Note

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Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect noradrenaline
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Minor High See all 4 studies
A decrease in noradrenaline appears to reliably occur after melatonin ingestion, but only at rest; this reduction is abolished upon moving
grade-b - Very High See all 3 studies
Peripheral concentrations of noradrenaline do not appear to be influenced by supplementation of cocoa.
grade-c Minor - See study
The reduction in noradrenaline levels seen in infertility is normalized following mucuna ingestion
grade-c Minor - See study
A decrease in exercise-induced noradrenaline has been noted before, but it is unsure if this is correct information (as this was the lone study to measure noradrenaline, three studies have measured adrenaline and are split with the only one noting a decrease in adrenaline also being this study)
grade-c - - See study
BCAA supplementation does not appear to significantly influence noradrenaline concentrations in serum
grade-c - - See study
No significant alterations in plasma noradrenaline are seen with creatine supplementation during sleep deprivation.
grade-c - - See study
No significant influence on plasma noradrenaline levels (despite increased plasma tyrosine) during rest or during a cold stress test (which increases noradrenaline)