Quick Navigation

Plasma Endorphins

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Plasma Endorphins

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Plasma Endorphins

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect plasma endorphins
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Notable - See study
The exercise-induced spike in endorphins appears to be related to the spike in acidity, and supplementation of bicarbonate is able to potently suppress the spike (although not abolish it)
grade-c - - See study
Plasma beta-endorphin is unaltered following ingestion of standard doses of gamma-oryzanol
grade-d Minor - See study
An increase in plasma endorphins has been noted with DHEA supplementation