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Plasma Nitrate

Oral ingestion of nitrate can increase plasma nitrate and nitrite, although they can also be used as biomarkers of nitric oxide metabolism by being able to be preserved and increased relative to their lower rate of decay. Higher plasma nitrate is associated with better blood flow.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect plasma nitrate
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Strong Very High See all 3 studies
Nitrate ingestion strongly and fairly reliabily increases plasma nitrate and nitrite.
grade-c Minor - See study
An increase in plasma nitrate has been noted with citrulline supplementation, but not to the degree of supplemental nitrate itself
grade-c Minor Very High See 2 studies
Plasma nitrate appears to be increased following carnitine ingestion, although not to the same degree as nitrate supplementation itself
grade-c - - See study
There does not appear to be a reliable increase in plasma nitrate seen with arginine supplementation
grade-c - - See study
Plasma nitrate concentrations do not appear to be altered with supplementation of niacin.
grade-c - - See study
No significant influence of zinc supplementation on plasma nitrate or nitrite levels, suggesting no interaction with nitric oxide metabolism