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Platelet Aggregation

Platelet aggregation is the rate of which platelets in the blood can form clots to stop bleeding. While it serves a vital role in preventing excessive bleeding, abnormally active aggregation can be a risk factor for cardiovascular diseases.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect platelet aggregation
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 4 studies
Possible decreases in platelet aggregation
grade-c Notable Very High See all 5 studies
Both acute and prolonged ingestion of reasonable levels of cocoa flavonoids (500mg or more) appear to reduce the aggregation of platelets, although the potency is lesser than that of a baby aspirin (81mg).
grade-c Minor Very High See all 4 studies
Garlic appears to reduce platelet aggregation at the supplemental dose, but not a moderate dietary dose of garlic cloves. The potency is less than ginkgo biloba as a reference.
grade-c Minor - See study
5g of the oil daily is able to reduce platelet aggregation in otherwise healthy persons.
grade-c - Moderate See 2 studies
While 100mg of γ-tocopherol has been once implicated in reducing platelet aggregation, higher doses and all tested dose of α-tocopherol by themselves do not appear to have an effect (there is still an interaction with warfarin, however).