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Pre-Eclampsia Risk

Pre-Eclampsia refers to a spike in blood pressure and proteinuria that some pregant women experience, and due to the severity of this condition some supplements are sought after for reducing the risk of it ever developing.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect pre-eclampsia risk
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 4 studies
Calcium supplementation appears to be quite potent in reducing the risk of pre-eclampsia when supplemented at 1,000mg a day, with more efficacy in those with lower dietary calcium intake.
grade-b Notable Very High See all 3 studies
Supplementation with selenium significantly reduces the incidence of pre-eclampsia.
grade-b - Very High See 2 studies
There does not appear to be a significant protective effect against pre-eclampsia in women who supplement fish oil during pregnancy
grade-c Minor - See study
A reduction in risk has been noted, but not to an overly amazing degree
grade-c - - See study
No significant influence on pre-eclampsia risk