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Proteinuria is losses of large protein structures in the urine, which normally does not occur and signifies structural damage to the kidneys. A higher rate of proteinuria correlates with worsened kidney damage, and reductions in proteinuria reflect improved renal function.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect proteinuria
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Notable - See study
The study in diabetics noting a reduction in urinary albumin noted a near halving over 8 weeks with a low dose of ginkgo.
grade-c Minor - See study
A reduction in proteinuria has been noted in persons with kidney impairment given curcumin
grade-c - Very High See 2 studies
No evidence to support a reduction in the amount of protein lost in the urine of persons with diabetic nephropathy (UAE between 15-300mg/24 hours). Whether there is a preventative effect or not, there does not appear to be a rehabilitative effect.
grade-c - - See study
Chromium supplementation does not appear to cause proteinuria (protein losses in the urine) suggesting no kidney toxicity, as proteinuria is a biomarker of such damage.
grade-c - - See study
There is no significant influence on protein losses in the urine (proteinuria).
grade-c - - See study
Although a trend to reduce protein losses in the urine was noted (which would be kidney protective), this was a statistically insignificant and secondary to lupus treatment
grade-c - - See study
No significant influence on the rate of proteinuria, suggesting no kidney damage associated with supplementation.
grade-d Minor - See study
Reduced proteinuria in pregnant women (possibly indiciative of kidney protective effects); more studies would be prudent as to include comparators or use in other contexts.
grade-d Minor - See study
A decrease in urinary protein has been noted, indicative of kidney protective effects