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Sex Hormone Binding Globulin

Sex Hormone Binding Globulin (SHBG) is a globulin that is able to bind to and sequester steroid hormones such as estrogen, testosterone, and DHT. Its elevations are associated with less activity of the steroid hormones.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Things To Know & Note

Also Known As

SHBG

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect sex hormone binding globulin
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor High See all 4 studies
There appears to be a decrease in SHBG concentrations in older individuals who also experience an increase in androgen/estrogen concentrations, but this is similarly unreliable
grade-b - Very High See all 6 studies
There are no significant alterations in the circulating levels of SHBG seen with red clover supplementation.
grade-c - - See study
In women with PCOS, chromium supplementation does not alter SHBG concentrations in serum.
grade-c - - See study
No significant influence on circulating SHBG over the course of 12 weeks in otherwise healthy men.
grade-c - - See study
No significant influence on SHBG levels
grade-c - - See study
grade-d - - See study
No significant alterations in SHBG levels following supplementation
grade-d - - See study
No significant change in men taking 1.5 g/d of a Tribulus extract