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Skeletal Muscle Atrophy

Skeletal muscle atrophy (catabolism) is the loss of lean muscle tissue over time or during inactivity. Compounds that increase atrophy can accelerate this loss while compounds that reduce atrophy are known as 'anti-catabolic'.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Things To Know & Note

Also Known As

Catabolism

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect skeletal muscle atrophy
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Minor - See study
The rate of muscle protein breakdown is decreased with clenbuterol usage
grade-c Minor - See study
May decrease the rate of skeletal muscle breakdown over time
grade-c - Very High See 2 studies
The study that noted a prevention of lean mass loss did not distinguish between water and muscle, while the study that measured muscle mass specifically failed to find a protective effect during limb immobilization.
grade-d - See study
Was able to attenuate the rate of skeletal muscle loss during a hypocaloric diet in obese persons; unknown if this applies to lean persons and may be related to ketone production.