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Sperm Quality

Sperm quality refers to the structural capacity of sperm cells and their ability to fertilize (and does not necessarily reflect sperm count nor motility). Supplements that improve sperm quality are thought to be pro-fertility agents.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect sperm quality
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable High See all 5 studies
Carnitine at 3g daily appears to increase sperm quality mostly related to sperm morphology; there are mixed effects on sperm motility
grade-b Minor Very High See all 3 studies
There appears to be an increase in seminal quality and oxidative parameters following 3-month ingestion of Mucuna pruriens, which is thought to be secondary to correcting the hypothalamic-pituitary-testes axis
grade-c Minor Very High See all 4 studies
Appears to enhance seminal quality (in a fairly general sense) but needs more studies against reference drugs to properly assess potency.
grade-c Minor Moderate See all 4 studies
There may be some beneficial influences on the sperm quality, but they have not been reliably reported
grade-c Minor - See study
May increase parameters of sperm quality and volume.
grade-c Minor - See study
Sperm quality (and thought to apply to fertiliy) has been improved with Shilajit supplementation
grade-c - - See study
grade-c - Very High See 2 studies
While preliminary evidence suggested benefit to seminal morphology, the best evidence to date does not support a role for saffron in enhancing seminal quality.
grade-c - Very High See 2 studies
The increase in sperm quality seen with 6g tribulus root has failed to outperform placebo in infertile men. Another uncontrolled study that used 2.25 g per day of a tribulus extract found significant improvements in multiple measures of semen/sperm quality.
grade-c - - See study
grade-d Minor - See study
Appears effective, needs to be compared against a comparator.
grade-d Minor - See study
Seminal viability (40.7%) and normal morphology () is increased in infertile men given ginger.