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Symptoms of Alzheimer’s

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Symptoms of Alzheimer’s

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Symptoms of Alzheimer’s

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of alzheimer’s
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor Very High See all 5 studies
Cognitive impairment that is associated with Alzheimer's appears to be significantly reduced with ginkgo supplementation.
grade-c Notable - See study
At least among nutraceuticals, Alpha-GPC appears to significantly improve cognition in persons with Alzheimer's disease at the dose of 1,200mg when taken as a daily supplement over a prolonged period of time.
grade-c Notable Very High See 2 studies
Very high dose Vitamin E supplementation in the form of α-tocopherol (2,000 IU) appears to reduce the rate of cognitive decline in persons with moderate to severe Alzheimer's Disease with a potency comparable to selegiline. Currently no research on lower (more standard) doses, and there appears to be no influence on minor AD or cognitive decline not characterized by AD.
grade-c Minor Very High See 2 studies
Mixed evidence on the efficacy of saffron, but it is possible that supplementation could delay an increase in symptoms without a therapeutic effect.
grade-c - - See study
Despite the benefit seen with high dose DHA in cognitive decline, there does not appear to be a proven significant protective effect in persons already with Alzheimer's
grade-c - Moderate See 2 studies
The preliminary evidence at this point in time using scyllo-inositol has failed to find a significant therapeutic benefit and myo-inositol shows a nonsignificant trend for improvement based on preliminary evidence.
grade-c - - See study
The lone study in persons with Alzheimer's rather than organic cognitive decline has failed to find any benefit associated with supplementation