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Symptoms of Bipolar Disorder

Bipolar disorder (a condition characterized by manic and depressive phases) may be influenced by various nutritional supplements, although one of the two phases may be unaffected while the other benefits.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Things To Know & Note

Also Known As

Manic-depressive disorder

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of bipolar disorder
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Minor Very High See all 5 studies
There appears to be reduced depressive symptoms in bipolar disorder when the depression is of a large magnitude (similar to the anti-depressant effects of fish oil in general). There may not be a reduction in depressive symptoms with lower severity depression (a trend to increase has been noted) and manic symptoms do not appear to be significantly influenced.
grade-c - - See study
The lone study in persons with bipolar disorder was one investigating addiction, and when measuring symptoms of bipolar disorder they failed to find any influence of supplementation on symptoms.
grade-c - Very High See 2 studies
Although a beneficial effect cannot fully be ruled out, the best evidence currently available does not support a significant role for inositol in the treatment of bipolar disorder.
grade-d Minor - See study
A modest reduction compared with placebo has been noted in one study which needs to be replicated.
grade-d Minor - See study
In persons with bipolar disorder given supplementation of chromium, benefits were only noted against depressive symptoms and while significant (statistically) were mild; manic symptoms were not affected.
grade-d Minor - See study
Depressive symptoms of bipolar disorder are fairly strongly reduced with uridine supplementation, but currently only open label studies are in existence