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Symptoms of Menopause

Symptoms of menopause (climacteric symptoms) are issues that affect women after menopause, such as hot flashes or disturbed sleep. Supplements that reduce these symptoms on self-report surveys are thought to help women cope with menopause.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of menopause
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Minor Very High See all 13 studies
Although there appears to be some benefit over placebo, more recent studies note that the magnitude of benefit is much less than previously though (in the past, a false positive occurred when unblinded studies noted remarkable benefits with black cohosh; the placebo effect appears to be quite potent in regards to menopause)
grade-a - Moderate See all 12 studies
While isolated studies have noted some benefits, the best evidence at this moment in time (Independently conducted and larger, better conducted, studies) tend to note no significant influence on the main climacteric symptoms such as hot flashes with supplementation.
grade-b Minor High See all 3 studies
May decrease some symptoms associated with menopause, mostly related to libido, but this is unreliable.
grade-c Notable Very High See all 4 studies
The effects of Pueraria Mirifica on menopausal symptoms appear to be potent, with one study suggesting comparable efficacy to estrogen replacement therapy itself. Requires more robust evidence, however.
grade-c Minor - See study
One study noted reduced symptoms associated with menopause; libido was possibly independently increased, but anxiety and depression appear to also be reduced.
grade-c Minor - See study
A decrease in some symptoms of menopause has been noted with Pycnogenol supplementation
grade-c Minor Very High See 2 studies
Limited evidence suggests efficacy in the treatment of menopausal symptoms with valerian extract, with one study measuring benefits to hot flash frequency and the other insomniac symptoms.
grade-c Minor - See study
Menopausal symptoms have been reduced, but this was mostly due to the reported antidepressant and anxiolytic properties of the mushroom.
grade-d Minor Very High See 2 studies
Decreases in menopausal symptoms have been noted with DHEA supplementation
grade-d Minor - See study
A decrease in symptoms related to menopause have been noted with Royal Jelly ingestion
grade-d - - See study
No significant influence detected on symptoms of menopause (as assessed by rating scales)