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Symptoms of Rheumatoid Arthritis

Rheumatoid arthritis is an autoimmune form of arthritis that is associated with increases in inflammation and edema at joints, usually the more flexible and softer joints such as the hands. Some supplements target rhematoid arthritis.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect symptoms of rheumatoid arthritis
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-c Notable - See study
500mg Krill oil reduced symptoms of osteoarthritis up to 30%, which is a pretty significant effect size that requires future research to investigate.
grade-c Minor - See study
Reductions in joint pain and swelling were somewhat minimal in magnitude
grade-c Minor - See study
Preliminary evidence suggests a mild decrease in symptoms of rheumatoid arthritis seen with high (3,000mg) supplemental doses of G-hesperidin.
grade-c Minor - See study
A modest reduction in symptoms of rheumatoid arthritis (9%) has been noted with ingestion of the seeds
grade-c Minor Very High See 2 studies
There appears to be mild benefits to joint symptoms in rheumatoid arthritis when rose hip is supplemented over the course of months, and these benefits may be seen at low (5g) dosages. Short term supplementation has not shown much benefit.
grade-c - - See study
No significant interaction between ALA supplementation and symptoms of rheumatoid arthritis
grade-c - - See study
Preliminary evidence has failed to find an effect of Feverfew on reducing symptoms of Rheumatoid arthritis
grade-c - - See all 3 studies
grade-c - Very High See 2 studies
No significant influence of velvet antler on symptoms of rheumatoid arthritis
grade-d Minor Very High See 2 studies
A small improvement in one study and a large improvement in another. Much more evidence is needed.