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Triglycerides

Triglycerides is a term used to refer to the circulating levels of fatty acids (similar in structure to dietary fatty acids, and fat mass) that can be measured via a blood test. Although crucial for energy usage, excessively high circulating Triglycerides is a risk factor for circulatory problems.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Feb 6, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect triglycerides
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-a Strong Very High See all 44 studies
Fish oil, both EPA and DHA, are reference drugs for the purpose of reducing triglycerides with highly reliable reductions in the range of 15-30% (higher reductions seen in persons with higher baseline triglycerides)
grade-a Minor Very High See all 15 studies
There appears to be quite an unreliable decrease in triglycerides following garlic supplementation. When looking at meta-analyses, there is either a significant but small decrease or a reduction that fails to reach statistical significance.
grade-a - Very High See all 17 studies
Chromium does not appear to have a role in reducing triglyceride concentrations in the serum of subjects, including diabetic subjects given chromium supplementation.
grade-a - Very High See all 16 studies
The vast majority of studies assessing either dark chocolate products or isolated polyphenolics from cocoa fail to find any influence on triglycerides relative to placebos or control chocolates.
grade-a - Very High See all 7 studies
There is no significant influence on triglycerides noted with supplementation of hesperidin; if an effect occurs, it is of very minor magnitude and only lasts for as long as supplementation persists.
grade-a - High See all 11 studies
Isolated reports have noted minor (less than 10%) reductions in triglycerides in overweight or hyperlipidemics mostly, but overall there is not a significant reduction in triglycerides noted with Red clover extract.
grade-b Notable Moderate See all 8 studies
In populations with metabolic syndrome or related morbidities (diabetes, hyperlipidemia, hypetension, etc.) spirulina in a variety of doses between 1-8g daily is able to reduce triglycerides up to 10-15%.
grade-b Notable Very High See all 8 studies
There appears to be a large decrease of triglycerides in subjects with dyslipidemia given pharmacological doses of niacin; the magnitude being greater than most supplements (but lesser than fish oil)
grade-b Minor Very High See all 5 studies
Degree of reduction according to meta-analysis was −0.48mmol/L (95% CI −0.57 to −0.39) which was not overly remarkable.
grade-b Minor Moderate See all 8 studies
May possible increase triglycerides, but is unreliable in doing so and not overly potent.
grade-b Minor Moderate See all 20 studies
Some reducing effects have been noted, but they seem to be unreliable and not overly potent
grade-b Minor Very High See all 4 studies
There may be a small decrease in triglycerides associated with supplementation of inositol to women with PCOS
grade-b Minor Moderate See all 8 studies
The decreases in triglycerides only affect those with high triglycerides, and the decrease scales with severity of hyperlipidemia (mild elevation of TGs is met with a 1-5% decrease, significantly elevated TGs are met with a 15-20% reduction).
grade-b - - See all 4 studies
grade-b - High See all 3 studies
Mixed evidence, but it seems that DHEA doesn't have a significant influence on triglycerides
grade-b - Very High See all 3 studies
No significant influence of grape seed extract on triglycerides even in a high risk population at a high oral intake of GSE (600mg)
grade-b - Very High See 2 studies
No significant influence on triglycerides
grade-b - - See all 3 studies
grade-b - Very High See all 6 studies
For the most part, no significant influence of magnesium supplementation on triglycerides
grade-b - Very High See all 5 studies
The majority of the evidence suggests that there is no impressive effect on triglycerides with olive phenolic consumption
grade-b - Moderate See all 5 studies
When excluding older cuban studies (which are highly suspicious) there is no evidence to support a reduction of triglycerides.
grade-b - Very High See all 4 studies
Currently, it does not seem like there is a significant influence of psyllium on circulating triglycerides
grade-b - Very High See all 12 studies
No significant influence on fasting or postprandial triglycerides seems apparent with Vitamin C
grade-b - Very High See all 8 studies
No evidence to support changes in triglycerides associated with vitamin E supplementation in any tested person.
grade-c Notable Moderate See all 4 studies
Mixed effects on triglycerides, but the lone study that noted a decrease noted comparable potency to pravastatin; requires more literature
grade-c Notable Very High See all 3 studies
The one trial using TTA to reduce triglycerides noted a reduction of around 15%, which is notable and requires replication
grade-c Minor Very High See all 5 studies
The best evidence at this point in time suggests a slight decrease in triglycerides seen with Ashwagandha supplementation, although it does not appear to extend to persons with normal triglyceride levels but occurs in those with metabolic impairments.
grade-c Minor - See study
Reduction in triglycerides is not overly potent and occurred alongside weight loss, which was likely a confounding factor.
grade-c Minor Moderate See 2 studies
The decrease seen in triglycerides in one study was statistically significance, but the average reduction in hyperlipidemics (16%) has a very large range
grade-c Minor Very High See 2 studies
There appears to be a decrease in triglycerides over time with ephedrine ingestion, which may be due to either the fat burning effects of ephedrine or the weight loss that tends to ensue
grade-c Minor - See study
May reduce triglyceride levels
grade-c Minor - See study
A decrease in circulating triglycerides is noted with fucoxanthine
grade-c Minor Moderate See 2 studies
There may be a small decrease in triglycerides (8% or so) in unhealthy persons, but this has not been observed in otherwise healthy individuals
grade-c Minor - See study
May decrease triglycerides
grade-c Minor - See study
A decrease in triglycerides has been noted, confounded with weight loss
grade-c Minor Very High See 2 studies
A decrease in triglycerides has been noted with krill oil
grade-c Minor Moderate See 2 studies
A possible reduction in triglycerides to a minor degree is noted with melatonin supplementation, but this is not reliable
grade-c Minor Moderate See 2 studies
A possible slight reduction in triglycerides has been noted with pomegranate oil, but this appears to be unreliable
grade-c Minor - See study
A decrease in triglycerides has been noted with resveratrol supplementation
grade-c Minor Moderate See 2 studies
A minor reduction of triglycerides occurs with daily ingestion of Rooibos tea only in unhealthy persons
grade-c Minor - See study
Minor decrease in triglycerides has been noted with shilajit
grade-c Minor Very High See 2 studies
A slight increase in triglycerides has been noted with vanadium supplementation
grade-c Minor - See study
The decrease in triglycerides is present after long term ingestion of Vitamin D, although it isn't to a highly significant degree
grade-c Minor Very High See 2 studies
Possible reductions in triglycerides, but it is not sure if this is exclusive to whey protein or due to protein in general.
grade-c - - See 2 studies
grade-c - Very High See all 4 studies
The two better controlled trials noted no change, whereas a decrease and increase has been noted otherwise. Unclear overall effects on triglycerides
grade-c - - See study
No significant influence on triglycerides.
grade-c - - See 2 studies
grade-c - Very High See 2 studies
No significant effect on triglyceride concentrations in serum
grade-c - Very High See 2 studies
No known interactions with serum triglycerides following supplementation of blueberries.
grade-c - - See study
No significant influence on triglyceride levels
grade-c - - See all 3 studies
grade-c - - See study
No significant influence on triglycerides
grade-c - - See study
No significant influence on triglycerides noted with ecklonia cava
grade-c - - See study
No significant influences yet known for triglycerides
grade-c - - See study
No significant alterations in plasma triglycerides seen with supplementation
grade-c - - See study
No detectable influence on triglyceride levels
grade-c - - See study
No significant influence on triglycerides following oral intake
grade-c - - See study
No apparent influence on triglycerides
grade-c - Very High See 2 studies
No significant influence of Guggul on triglycerides is detectable
grade-c - - See study
No significant alterations in triglycerides noted with supplementation
grade-c - Very High See 2 studies
No significant influence of oral hemp seeds on triglycerides
grade-c - - See study
No significant influence of Japanese Knotweed on triglycerides
grade-c - - See study
grade-c - - See study
No significant influence on triglycerides
grade-c - - See study
No significant influence on fasting triglycerides noted
grade-c - - See study
No significant influence on triglycerides
grade-c - Very High See 2 studies
No significant alterations in triglycerides and fatty acids in the fasted state or during exercise
grade-c - - See study
grade-c - - See study
No significant influence on triglycerides seen at rest or during exercise with PS supplementation
grade-c - - See study
There do not appear to be any interactions on triglycerides in adults with normal triglyceride levels given pterostilbene supplementation.
grade-c - Very High See 2 studies
No significant influence of rose hip on triglyceride concentrations has been noted.
grade-c - Very High See all 3 studies
Although there may be a reduction in triglycerides associated with Royal Jelly, currently the best evidence suggests no such change
grade-c - Very High See 2 studies
No significant influence on triglycerides
grade-c - - See study
Although it may attenuate postprandial lipidemia (spikes in triglycerides following a meal), supplementation does not appear to significantly affect fasting triglyceride concentrations.
grade-c - - See study
No significant influence on triglycerides
grade-c - - See study
No significant influence on circulating triglycerides has been noted with stevia consumption
grade-c - - See study
No significant influence of theaflavins on triglycerides (hypercholesterolemic persons)
grade-c - Moderate See 2 studies
No significant alterations in serum triglycerides are noted with prolonged supplementation of betaine supplementation.
grade-c - - See study
No significant influence on circulating triglycerides seen with MK-4 supplementation
grade-c - - See study
Despite a triglcyeride reducing effect of fructooligosaccharides in rats, the limited evidence in humans (with mildly elevated triglcyerides) failed to find any appreciable effect despite weight loss.
grade-c - Very High See 2 studies
No significant reduction in circulating triglycerides has been detected with zinc supplementation.
grade-d Minor - See study
Requires more studies before conclusions can be made, appears to simply be exerting anti-oxidant effects.
grade-d Minor - See study
In type II diabetics, triglycerides in fasting conditions were noted to be reduced relative to baseline with colostrum ingestion.
grade-d Minor - See study
Decreases in triglycerides have been noted, but not to a remarkable degree
grade-d Minor - See study
Appears to have triglyceride reducing properties
grade-d - - See study
No significant influence on triglycerides
grade-d - - See study
grade-d - - See study
Insufficient evidence to support changes in serum triglycerides.
grade-d - - See study
grade-d - - See study
No significant alterations on triglycerides
grade-d - - See study
Short term supplementation of PQQ has failed to significantly influence triglycerides in otherwise healthy adults
grade-d - - See study
No significant influence of this berry on the triglycerides of otherwise healthy men.
grade-d - - See study
No significant influence on circulating triglycerides in diabetic persons given ruscus aculeatus supplementation.
grade-d - - See study
No significant alterations in triglyceride concentrations
grade-d - Moderate See 2 studies
While a modest reduction is possible, the results of two studies didn't find significant differences relative to placebo.
grade-d - - See study
No observed changes in a population with hyperglycemia