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Uric Acid

Uric acid is a molecule (a byproduct of purine metabolism) that, in excessive levels, can contribute to gout and kidney stones. Despite this, uric acid is a potent antioxidant compound.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect uric acid
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-c Minor Very High See 2 studies
A minor reduction has been observed.
grade-c Minor - See study
An increase in serum urate has been noted in the range of 10-20% acutely, but attenuates with time and is likely not a concern within a week. Practical significance of this increase unknown.
grade-c Minor - See study
A decrease in uric acid has been noted
grade-c Minor - See study
An 11% decrease in uric acid has been noted in diabetics supplementing with psyllium husk.
grade-c - - See study
Serum uric acid/urate seems unaltered in response to cocoa flavanol supplementation.
grade-c - - See study
grade-c - - See study
No changes in serum uric acid seem apparent
grade-c - - See study
No significant influences on uric acid
grade-c - Moderate See 2 studies
No statistically significant alterations in uric acid concentrations in serum
grade-c - - See study
No significant influence on uric acid concentrations
grade-c - - See study
No significant influence on uric acid is seen with Rooibos tea ingestion.
grade-c - - See study
The uric acid/urate balance is not affected by supplementation of riboflavin.
grade-d Minor Very High See 2 studies
A small decrease in patients with non-alcoholic fatty liver disease has been noted. Much more evidence is needed.
grade-d - - See study
No significant interactions with uric acid concentrations in serum.
grade-d - - See study
Does not appear to influence uric acid concentrations in serum
grade-d - Very High See 2 studies
No significant alterations in serum uric acid seen with supplemental TTA
grade-d - Moderate See 2 studies
Possibly attenuates an increase from extreme exercise but it's unclear and especially unclear for other circumstances.