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Very low density cholesterol (vLDL-C) is the lipoprotein synthesized in the liver, and is able to convert to LDL-C when in circulation.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect vldl-c
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
grade-b Minor Very High See all 6 studies
May decrease vLDL cholesterol
grade-b - Very High See all 4 studies
No significant influence on vLDL cholesterol seen in diabetics supplementing chromium.
grade-c Notable Very High See 2 studies
Alongside decreases in triglycerides and LDL-C, the concentrations of vLDL-C also appear to be decreased in response to niacin supplementation.
grade-c Minor - See study
Minor decreases in vLDL concentrations have been noted
grade-c - - See study
grade-c - Very High See 2 studies
vLDL-C concentrations in serum do not appear to be altered in response to supplementation of cocoa flavanols.
grade-c - - See study
grade-c - - See study
No significant influence on vLDL cholesterol levels
grade-c - - See study
No significant changes in vLDL-C are detected with quercetin supplementation.
grade-d Minor - See study
Decreases in fasting vLDL have been noted
grade-d - Moderate See 2 studies
A reduction has been noted in one industry-funded study when 250 mg or 500 mg of an extract was used. Another study in healthy, active participants found no change.
grade-d - Moderate See 2 studies
A notable reduction was found in coronary artery disease patients in a small pilot study, but not in another study in type 2 diabetics that used turmeric. Much more research is needed.