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White Blood Cell Count

Total white blood cell count is measured commonly in toxicology testing, and some supplements that are known to support the immune system may also act via increasing levels of immune cells.

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jul 5, 2013
Last Updated:

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect white blood cell count
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b - Very High See all 3 studies
While there are signficant modifications in the subpopulations of white blood cells (ie. which immune cells you have) the overall quantity does not appear significantly affected.
grade-b - Very High See all 6 studies
Supplementation of vitamin E does not appear to alter overall content of white blood cells relative to placebo.
grade-c Minor Moderate See 2 studies
A decrease in white blood cell count has been noted with supplementation of saffron at 60mg for over eight weeks.
grade-c Minor - See study
Minor increase, needs more evidence in a non-aged cohort to assess potency
grade-c - - See study
grade-c - - See 2 studies
grade-c - Moderate See 2 studies
White blood cell count does not appear to be chronically modified with colostrum supplementation, although a transient (one day) elevation was noted in one study.
grade-c - - See study
In safety testing, no significant alterations in white blood cell count is noted.
grade-c - - See study
No significant alterations in WBC count
grade-c - - See study
No significant influence on total white blood cell count is seen with supplemental hesperidin.
grade-c - - See 2 studies
grade-d Minor Moderate See 2 studies
During toxicology testing in otherwise healthy persons, there was no significant alterations in white blood cell count seen with supplementation. However, another study found a statistically significant increase in healthy, active participants.
grade-d Minor - See study
A normalization of WBC count has been noted in persons with hepatitis C being treated with the seed oil.
grade-d Minor - See study
An increase in white blood cell count has been noted with Cat's Claw by 9% over 9 weeks with a water extract, which is thought to be related to the immunoenhancing properties. The white blood cells that were increased were not assessed
grade-d - High See all 3 studies
Inconsistent evidence from 3 studies. Much more research is needed.
grade-d - - See study
No change in white blood cell count in one study.
grade-d - - See study
No significant alterations in white blood cell count following ingestion of the seeds of Moringa oleifera
grade-d - - See study
No significant alterations in white blood cell count are noted with oral supplementation of this plant.
grade-d - - See study