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Wrinkles

Research analysis led by Kamal Patel.
All content reviewed by the Examine.com Team. Published: Jun 28, 2017
Last Updated:

Summary of Wrinkles

Primary Information, Benefits, Effects, and Important Facts

Scientific Information on Wrinkles

Human Effect Matrix

The Human Effect Matrix looks at human studies (it excludes animal and in vitro studies) to tell you what supplements affect wrinkles
Grade Level of Evidence
Robust research conducted with repeated double-blind clinical trials
Multiple studies where at least two are double-blind and placebo controlled
Single double-blind study or multiple cohort studies
Uncontrolled or observational studies only
Level of Evidence
? The amount of high quality evidence. The more evidence, the more we can trust the results.
Outcome Magnitude of effect
? The direction and size of the supplement's impact on each outcome. Some supplements can have an increasing effect, others have a decreasing effect, and others have no effect.
Consistency of research results
? Scientific research does not always agree. HIGH or VERY HIGH means that most of the scientific research agrees.
Notes
grade-b Notable Very High See all 3 studies
The appearance of fine (small) wrinkles appears to be reliably reduced with topical application of a nightly vitamin A cream, with efficacy in all ages assuming fine wrinkles are present.
grade-c Minor - See study
Topical application of nicotinamide appears to slightly reduce the appearance of fine wrinkles (crow's feet).
grade-d Minor - See study
There appears to be a slight decrease in skin wrinkling following topical application of 0.3% ginkgo for 28 days
grade-d Minor - See study
Application of a 3% moringa leaf cream for three winter months in young adult males appeared to reduce visual wrinkles on the cheeks relative to control cream.
grade-d Minor - See study
3 g of oral rose hip powder decreased the depth of crow's feet wrinkles.